Read e-book online Antioxidants in Biology and Medicine: Essentials, Advances, PDF

By Professor and Chair Dr Yunbo Li

ISBN-10: 161209466X

ISBN-13: 9781612094663

It is a ebook that takes a different method of integrating wisdom in antioxidants from necessities to advances, and from simple examine to scientific functions. This booklet provides clinical details on antioxidants in an organised, cogent, and in-depth demeanour. The constant structure of writing, the full-colour illustrations, and the great record of references make the ebook available and fascinating. in addition to its worth as a textbook for undergraduate and graduate scholars in existence technological know-how, "Antioxidants in Biology and medication" may also be an invaluable reference for biomedical learn scientists, clinicians, and different health and wellbeing execs.

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Extra info for Antioxidants in Biology and Medicine: Essentials, Advances, and Clinical Applications

Sample text

MnSOD exists in mitochondrial matrix. ECSOD is associated with plasma membrane or present in extracellular space. The human genes for Cu,ZnSOD, MnSOD, and ECSOD are localized on chromosomes 21q22, 6q25, and 4q21, respectively. Table 3-1 summarizes the basic characteristics of the three SOD isozymes in mammals. Table 3-1. Basic Characteristics of the three isozymes of mammalian superoxide dismutase Isozyme Cu,ZnSOD Molecular Mass 32 kDa Assembly of Subunits Homodimer Metal Ions Cu and Zn MnSOD 86-88 kDa Homotetramer Mn ECSOD 135 kDa Homotetramer Cu and Zn Cellular Location Cytosol, nuclei, mitochondrial intermembrane space Mitochondrial matrix Plasma membrane, extracellular space Chromosomal Localization 21q22 6q25 4q21 2.

2005;25:5933-5946. Rushmore TH, Morton MR, Pickett CB. The antioxidant responsive element: activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. J. Biol. Chem. 1991;266:11632-11639. Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y, et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun. 1997;236:313-322. Maher J, Yamamoto M.

Circulation 2008; 117:2142-2150. Yen HC, Oberley TD, Vichitbandha S, Ho YS, St Clair DK. The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in Superoxide Dismutase [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] [24] [25] 43 transgenic mice. J. Clin. Invest 1996;98:1253-1260. Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, et al. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase.

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Antioxidants in Biology and Medicine: Essentials, Advances, and Clinical Applications by Professor and Chair Dr Yunbo Li


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