Download PDF by Edwin H. Flynn: Cephalosporins and Penicillins. Chemistry and Biology

By Edwin H. Flynn

ISBN-10: 012261450X

ISBN-13: 9780122614507

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The enzyme from the latter organism was active on phenoxymethylpenicillin, much less active on phenylmercaptomethylpenicillin, and not active on benzyl­ penicillin. The reverse order of activity was found to be true for the enzyme of E. coli. Claridge et al. (1963) reported that acylases of bacterial origin would not hydrolyze synthetic penicillins containing a carboxyl group on the side chain, but a strain of Pénicillium chrysogenum was able to hydrolyze some of the substances. Other examples of the preference of fungal systems for side chains other than phenylacetic acid have been reported by Erickson and Bennett (1965) and Uri et al.

Brandi (1965) compared the acylases isolated from E. coli and F. semitectum. The enzyme from the latter organism was active on phenoxymethylpenicillin, much less active on phenylmercaptomethylpenicillin, and not active on benzyl­ penicillin. The reverse order of activity was found to be true for the enzyme of E. coli. Claridge et al. (1963) reported that acylases of bacterial origin would not hydrolyze synthetic penicillins containing a carboxyl group on the side chain, but a strain of Pénicillium chrysogenum was able to hydrolyze some of the substances.

1948). Lavori dell'istituto D'Igiene di Cagliari. Burton, H. , and Abraham, E. P. (1951). Biochem. J. 50, 168. Burton, H. , Abraham, E. , and Cardwell, H. M. E. (1956). Biochem. J. 62, 171. 1. , Florey, H. , Jennings, M. , and Williams, T. I. (1943). Brit. J. Exp. Pathol. 24,108. Chou, T. , Eisenbraun, E. , and Rapala, R. T. (1969). Tetrahedron 25, 3341. Clark, R. , Fricke, H. , and Lanius, B. (1956-57). In "Antibiotics Annual" (H. Welch and F. ), p. 749. Medical Encyclopedia, New York. , Heatley, N.

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Cephalosporins and Penicillins. Chemistry and Biology by Edwin H. Flynn


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