Get Chemokine Receptors in Cancer PDF

By Chareeporn Akekawatchai, Marina Kochetkova, Jane Holland (auth.), Amy M. Fulton (eds.)

ISBN-10: 1603272666

ISBN-13: 9781603272667

Chemokine Receptors in melanoma summarizes the turning out to be physique of proof that a number of chemokine receptors give a contribution to tumor habit. Chemokine receptors have been first pointed out on leukocytes and mediate directed migration of many host cells to websites of ligand expression. it's now good demonstrated that the majority malignant cells additionally convey a number of chemokine receptor. This booklet describes our present knowing concerning how chemokine receptors give a contribution to tumor mobilephone migration in addition to mobile survival and proliferation. The functionality of chemokine receptors expressed on host cells together with antitumor immune effector cells in addition to angiostatic and angiogeneic services of chemokines performing on endothelial cells are defined. The function of chemokine receptors that act as decoy receptors is additionally summarized. The healing capability and demanding situations of focusing on chemokine receptors or cognate ligands is additionally addressed.

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Murphy, P. M. (2001). Chemokines and the molecular basis of cancer metastasis. N Engl J Med 345(11): 833–5. 76. , et al. (2005). Selective infiltration of CCR5(+)CXCR3(+) T lymphocytes in human colorectal carcinoma. Int J Cancer 116(6): 949–56. 77. , et al. (1996). Defects of B-cell lymphopoiesis and bonemarrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382(6592): 635–8. 78. , Hortobagyi, G. , et al. (2003). Growth factor receptors in breast cancer: potential for therapeutic intervention.

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90. Polyak, K. (2001). On the birth of breast cancer. Biochim Biophys Acta 1552(1): 1–13. 91. Pyne, N. , et al. (2003). Receptor tyrosine kinase-GPCR signal complexes. Biochem Soc Trans 31(Pt 6): 1220–5. 92. Rahmatullah, M. and Robishaw, J. D. (1994). Direct interaction of the alpha and gamma subunits of the G proteins. Purification and analysis by limited proteolysis. J Biol Chem 269(5): 3574–80. 93. , et al. (2005). Membrane rafts segregate pro- from anti-apoptotic insulin-like growth factor-I receptor signaling in colon carcinoma cells stimulated by members of the tumor necrosis factor superfamily.

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Chemokine Receptors in Cancer by Chareeporn Akekawatchai, Marina Kochetkova, Jane Holland (auth.), Amy M. Fulton (eds.)

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